Child development following in utero exposure: Levetiracetam vs sodium valproate

Children born to women with epilepsy (WWE), exposed in utero to levetiracetam (LEV, n = 51), were assessed for early cognitive development and compared to children exposed to sodium valproate in utero (VPA, n = 44) and a group of children representative of the general population (n = 97). Children w...

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Veröffentlicht in:	Neurology 2011-01, Vol.76 (4), p.383-389
Hauptverfasser:	SHALLCROSS, R, BROMLEY, R. L, IRWIN, B, BONNETT, L. J, MORROW, J, BAKER, G. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - adverse effects Biological and medical sciences Child Development Child, Preschool Cognition Epilepsy - drug therapy Female Humans Infant Injuries of the nervous system and the skull. Diseases due to physical agents Maternal Exposure Maternal-Fetal Exchange Medical sciences Neurology Piracetam - adverse effects Piracetam - analogs & derivatives Pregnancy Pregnancy Complications - drug therapy Prenatal Exposure Delayed Effects - physiopathology Prenatal Exposure Delayed Effects - psychology Retrospective Studies Traumas. Diseases due to physical agents Valproic Acid - adverse effects
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Zusammenfassung:	Children born to women with epilepsy (WWE), exposed in utero to levetiracetam (LEV, n = 51), were assessed for early cognitive development and compared to children exposed to sodium valproate in utero (VPA, n = 44) and a group of children representative of the general population (n = 97). Children were recruited prospectively from 2 cohorts in the United Kingdom and assessed using the Griffiths Mental Development Scale (1996), aged
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.0b013e3182088297