Immunotherapy for the treatment of glioblastoma

Glioblastoma, the most aggressive primary brain tumor, thrives in a microenvironment of relative immunosuppression within the relatively immune-privileged central nervous system. Despite treatments with surgery, radiation therapy, and chemotherapy, prognosis remains poor. The recent success of immun...

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Veröffentlicht in:	The cancer journal (Sudbury, Mass.) Mass.), 2012-01, Vol.18 (1), p.59-68
Hauptverfasser:	Thomas, Alissa A, Ernstoff, Marc S, Fadul, Camilo E
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - immunology Brain Neoplasms - therapy Glioblastoma - immunology Glioblastoma - therapy Humans Immunotherapy - methods
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Beschreibung
Zusammenfassung:	Glioblastoma, the most aggressive primary brain tumor, thrives in a microenvironment of relative immunosuppression within the relatively immune-privileged central nervous system. Despite treatments with surgery, radiation therapy, and chemotherapy, prognosis remains poor. The recent success of immunotherapy in the treatment of other cancers has renewed interest in vaccine therapy for the treatment of gliomas. In this article, we outline various immunotherapeutic strategies, review recent clinical trials data, and discuss the future of vaccine therapy for glioblastoma.
ISSN:	1528-9117 1540-336X
DOI:	10.1097/PPO.0b013e3182431a73