Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells

The role of taurine in regulating glucose-induced nitrosative stress has been examined in human Schwann cells, a model for understanding the pathogenesis of diabetic neuropathy. Exposure to high glucose increased nitrated proteins (1.56 fold p

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Bibliographische Detailangaben
Veröffentlicht in:	Experimental neurology 2012-01, Vol.233 (1), p.154-162
Hauptverfasser:	Askwith, Trevor, Zeng, Wei, Eggo, Margaret C., Stevens, Martin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Biological and medical sciences Cell Survival - drug effects Cells, Cultured Development. Senescence. Regeneration. Transplantation Dose-Response Relationship, Drug Drug Interactions Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Glucose - pharmacology Humans Hyperglycemia and Nitric oxide in Schwann cells Imidazolidines - pharmacology Male MAP Kinase Signaling System - drug effects Medical sciences Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Molsidomine - analogs & derivatives Molsidomine - pharmacology Neurology Nitrates - metabolism Nitric Oxide Donors - pharmacology Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type I - genetics Nitric Oxide Synthase Type I - metabolism Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitroprusside - pharmacology Nitrosation - drug effects RNA, Messenger - metabolism Schwann Cells - drug effects Taurine - metabolism Taurine - pharmacology Thioctic Acid - pharmacology Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	The role of taurine in regulating glucose-induced nitrosative stress has been examined in human Schwann cells, a model for understanding the pathogenesis of diabetic neuropathy. Exposure to high glucose increased nitrated proteins (1.56 fold p
ISSN:	0014-4886 1090-2430
DOI:	10.1016/j.expneurol.2011.09.010