RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice

RASA1 (also known as p120 RasGAP) is a Ras GTPase-activating protein that functions as a regulator of blood vessel growth in adult mice and humans. In humans, RASA1 mutations cause capillary malformation-arteriovenous malformation (CM-AVM); whether it also functions as a regulator of the lymphatic v...

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Veröffentlicht in:	The Journal of clinical investigation 2012-02, Vol.122 (2), p.733-747
Hauptverfasser:	Lapinski, Philip E, Kwon, Sunkuk, Lubeck, Beth A, Wilkinson, John E, Srinivasan, R Sathish, Sevick-Muraca, Eva, King, Philip D
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Ascites Biomedical research Blood vessels Cell Proliferation Diaphragm (Anatomy) Endothelial Cells - cytology Endothelial Cells - physiology Extracellular Signal-Regulated MAP Kinases - metabolism Female Genetic aspects Growth factors Humans Hyperplasia Lymphangiogenesis - physiology Lymphatic diseases Lymphatic Diseases - pathology Lymphatic Diseases - physiopathology Lymphatic Vessels - cytology Lymphatic Vessels - pathology Lymphatic Vessels - physiology Mice Mice, Inbred C57BL Mice, Transgenic MicroRNAs Mutation p120 GTPase Activating Protein - genetics p120 GTPase Activating Protein - metabolism Physiological aspects Proto-Oncogene Proteins c-akt - metabolism Ras genes ras GTPase-Activating Proteins - genetics ras GTPase-Activating Proteins - metabolism Risk factors Signal transduction Signal Transduction - physiology Vascular endothelial growth factor Vascular Endothelial Growth Factor Receptor-3 - genetics Vascular Endothelial Growth Factor Receptor-3 - metabolism
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