Tremor reduction and modeled neural activity during cycling thalamic deep brain stimulation

Highlights ► Tremor and firing pattern entropy of model neurons decreased from baseline levels with cycling stimulation. ► Cycling with stimulation on for at least 60% of the time was as effective as continuous 125 Hz stimulation at reducing tremor. ► Cycling stimulation decreased the firing pattern...

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Veröffentlicht in:	Clinical neurophysiology 2012-05, Vol.123 (5), p.1044-1052
Hauptverfasser:	Kuncel, Alexis M, Birdno, Merrill J, Swan, Brandon D, Grill, Warren M
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Aged Aged, 80 and over Analysis of Variance Biological and medical sciences Biophysics Computational model Computer Simulation Deep Brain Stimulation - methods Electrical stimulation Electrodiagnosis. Electric activity recording Entropy Essential tremor Female Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Models, Neurological Movement disorders Nervous system Neurology Neurons - physiology Thalamus Time Factors Tremor - pathology Tremor - therapy Ventral Thalamic Nuclei - physiology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights ► Tremor and firing pattern entropy of model neurons decreased from baseline levels with cycling stimulation. ► Cycling with stimulation on for at least 60% of the time was as effective as continuous 125 Hz stimulation at reducing tremor. ► Cycling stimulation decreased the firing pattern entropy of model neurons by regularizing pathological bursting, while pauses in stimulation generated rebound bursts and allowed transmission of pathological bursts.
ISSN:	1388-2457 1872-8952
DOI:	10.1016/j.clinph.2011.07.052