Angiopoeitin-2 modulates Survivin expression in OxLDL-induced endothelial cell apoptosis

► OxLDL down-regulated the expression of Ang-2 and Survivin. ► Survivin is a target gene of Ang-2. ► Ang-2 attenuates the OxLDL-mediated down-regulation of Survivin. ► Overexpression of Survivin attenuated OxLDL-induced HAEC apoptosis. Angiopoeitin-2 (Ang-2) antagonizes Angiopeitin-1 (Ang-1)-mediated Tie-2 signaling. Ang-1 is reported to up-regulate anti-apoptotic Survivin expression. Here, we investigated the interplay between Ang-2 and Survivin in response to oxidized low density lipoprotein (OxLDL)-induced apoptosis. We demonstrate that treatment of human aortic endothelial cells (HAEC) with 100μg/ml of OxLDL down-regulated Ang-2 expression as early as 4h after treatment and persisted up to 24h (p