Aggressive peripheral CD70-positive t-cell lymphoma associated with severe chronic active EBV infection

Severe chronic active Epstein–Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T‐cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T‐cell lymphoma expresses CD70 and is sensitive to killing by CD70‐specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV‐associated T‐cell lymphoma. Pediatr Blood Cancer 2012;59:758–761. © 2011 Wiley Periodicals, Inc.