Age‐associated elevation in TLR5 leads to increased inflammatory responses in the elderly

Summary Aging is accompanied by a progressive decline in immune function. Studies have shown age‐related decreases in the expression and signaling efficiency of Toll‐like receptors (TLRs) in monocytes and dendritic cells and dysregulation of macrophage TLR3. Using a multivariable mixed effect model,...

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Veröffentlicht in:	Aging cell 2012-02, Vol.11 (1), p.104-110
Hauptverfasser:	Qian, Feng, Wang, Xiaomei, Zhang, Lin, Chen, Shu, Piecychna, Marta, Allore, Heather, Bockenstedt, Linda, Malawista, Stephen, Bucala, Richard, Shaw, Albert C., Fikrig, Erol, Montgomery, Ruth R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Aged, 80 and over Aging Aging - immunology Aging - metabolism Cell activation Dendritic cells Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - immunology Extracellular Signal-Regulated MAP Kinases - metabolism Female flagellin Geriatrics Humans IL‐8 Immune response Immunology immunosenescence Inflammation Inflammation - immunology Inflammation - metabolism Interleukin 8 Interleukin-8 - biosynthesis Interleukin-8 - immunology Macrophages Male MAP kinase Medical research Middle Aged Monocytes Monocytes - immunology Monocytes - metabolism mRNA Multivariate Analysis NF- Kappa B protein NF-kappa B - immunology NF-kappa B - metabolism Older people Original p38 Mitogen-Activated Protein Kinases - immunology p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Protein Transport RNA, Messenger - biosynthesis Signal Transduction - immunology TLR3 protein TLR5 protein Toll-Like Receptor 5 - immunology Toll-like receptors Tumor necrosis factor- alpha Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - immunology
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Zusammenfassung:	Summary Aging is accompanied by a progressive decline in immune function. Studies have shown age‐related decreases in the expression and signaling efficiency of Toll‐like receptors (TLRs) in monocytes and dendritic cells and dysregulation of macrophage TLR3. Using a multivariable mixed effect model, we report a highly significant increase in TLR5‐induced production of IL‐8 from monocytes of older individuals (P
ISSN:	1474-9718 1474-9726
DOI:	10.1111/j.1474-9726.2011.00759.x