Herpes simplex serious neurological disease in young children: incidence and long-term outcome
Objective To determine the contribution of herpes simplex virus (HSV) to serious neurological disease. Setting and patients A 3-year prospective survey of children aged 2–23 months in Britain and Ireland. Results 19 children had HSV central nervous system (CNS) infection; 13 aged 2–11 months had foc...
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| Veröffentlicht in: | Archives of disease in childhood 2012-02, Vol.97 (2), p.162-165 |
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| creator | Ward, Katherine N Ohrling, Anu Bryant, Naomi J Bowley, Jennifer S Ross, Euan M Verity, Christopher M |
| description | Objective To determine the contribution of herpes simplex virus (HSV) to serious neurological disease. Setting and patients A 3-year prospective survey of children aged 2–23 months in Britain and Ireland. Results 19 children had HSV central nervous system (CNS) infection; 13 aged 2–11 months had focal neuroimaging abnormalities and 11 long-term neurological sequelae. Of six aged 12–35 months, one had abnormal neuroimaging and three long-term neurological sequelae. 17 of the 19 had serious neurological disease. HSV CNS infection accounted for 23% of serious neurological disease in children aged 2–11 months and 4.5% in older children. Conclusions The incidence of HSV-induced serious neurological disease in the UK was estimated at 1 in 64 000/year in younger children and 1 in 230 000 in older children. HSV CNS infection has clinical effects ranging from frank encephalitis to severe illness with fever and convulsions to milder disease lacking encephalopathy. |
| doi_str_mv | 10.1136/adc.2010.204677 |
| format | Article |
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Setting and patients A 3-year prospective survey of children aged 2–23 months in Britain and Ireland. Results 19 children had HSV central nervous system (CNS) infection; 13 aged 2–11 months had focal neuroimaging abnormalities and 11 long-term neurological sequelae. Of six aged 12–35 months, one had abnormal neuroimaging and three long-term neurological sequelae. 17 of the 19 had serious neurological disease. HSV CNS infection accounted for 23% of serious neurological disease in children aged 2–11 months and 4.5% in older children. Conclusions The incidence of HSV-induced serious neurological disease in the UK was estimated at 1 in 64 000/year in younger children and 1 in 230 000 in older children. HSV CNS infection has clinical effects ranging from frank encephalitis to severe illness with fever and convulsions to milder disease lacking encephalopathy.</description><identifier>ISSN: 0003-9888</identifier><identifier>ISSN: 1468-2044</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.2010.204677</identifier><identifier>PMID: 21685219</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Age Factors ; Anatomy ; Biological and medical sciences ; Central nervous system ; Cerebrospinal fluid ; Child development ; Children & youth ; Convulsions & seizures ; Developmental Delays ; Encephalitis ; Encephalitis, Herpes Simplex - complications ; Encephalitis, Herpes Simplex - diagnosis ; Encephalitis, Herpes Simplex - epidemiology ; Ethics ; Female ; Fever ; Fever - epidemiology ; Fever - virology ; General aspects ; Herpes simplex virus ; Herpes viruses ; Human viral diseases ; Humans ; Illnesses ; Incidence ; Infant ; Infections ; Infectious diseases ; Ireland - epidemiology ; Male ; Medical imaging ; Medical sciences ; Miscellaneous ; Neonates ; Nervous system ; Neuroimaging ; Prevention and actions ; Prognosis ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Questionnaires ; Seizures - epidemiology ; Seizures - virology ; Short Reports ; United Kingdom - epidemiology ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><ispartof>Archives of disease in childhood, 2012-02, Vol.97 (2), p.162-165</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2012 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b555t-b37cd6d2c172fd354a7ce68caba32e7c73eb9dd512fc2c0f25eb3835106269053</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://adc.bmj.com/content/97/2/162.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttp://adc.bmj.com/content/97/2/162.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>114,115,230,314,776,780,881,3183,23550,27901,27902,77342,77373</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25429152$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21685219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ward, Katherine N</creatorcontrib><creatorcontrib>Ohrling, Anu</creatorcontrib><creatorcontrib>Bryant, Naomi J</creatorcontrib><creatorcontrib>Bowley, Jennifer S</creatorcontrib><creatorcontrib>Ross, Euan M</creatorcontrib><creatorcontrib>Verity, Christopher M</creatorcontrib><title>Herpes simplex serious neurological disease in young children: incidence and long-term outcome</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>Objective To determine the contribution of herpes simplex virus (HSV) to serious neurological disease. Setting and patients A 3-year prospective survey of children aged 2–23 months in Britain and Ireland. Results 19 children had HSV central nervous system (CNS) infection; 13 aged 2–11 months had focal neuroimaging abnormalities and 11 long-term neurological sequelae. Of six aged 12–35 months, one had abnormal neuroimaging and three long-term neurological sequelae. 17 of the 19 had serious neurological disease. HSV CNS infection accounted for 23% of serious neurological disease in children aged 2–11 months and 4.5% in older children. Conclusions The incidence of HSV-induced serious neurological disease in the UK was estimated at 1 in 64 000/year in younger children and 1 in 230 000 in older children. HSV CNS infection has clinical effects ranging from frank encephalitis to severe illness with fever and convulsions to milder disease lacking encephalopathy.</description><subject>Age Factors</subject><subject>Anatomy</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Cerebrospinal fluid</subject><subject>Child development</subject><subject>Children & youth</subject><subject>Convulsions & seizures</subject><subject>Developmental Delays</subject><subject>Encephalitis</subject><subject>Encephalitis, Herpes Simplex - complications</subject><subject>Encephalitis, Herpes Simplex - diagnosis</subject><subject>Encephalitis, Herpes Simplex - epidemiology</subject><subject>Ethics</subject><subject>Female</subject><subject>Fever</subject><subject>Fever - epidemiology</subject><subject>Fever - virology</subject><subject>General aspects</subject><subject>Herpes simplex virus</subject><subject>Herpes viruses</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Ireland - epidemiology</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Neonates</subject><subject>Nervous system</subject><subject>Neuroimaging</subject><subject>Prevention and actions</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Questionnaires</subject><subject>Seizures - epidemiology</subject><subject>Seizures - virology</subject><subject>Short Reports</subject><subject>United Kingdom - epidemiology</subject><subject>Viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><issn>0003-9888</issn><issn>1468-2044</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkdtrFDEUh4Modq0--yYDIoIwbS6Ty_RBkMW2QlEQ9cEHQyY5s806k6zJjLT_vVl2XS8vfQon58vhl_Mh9JTgE0KYODXOnlBcKoobIeU9tCCNUHWpmvtogTFmdauUOkKPcl5jTKhS7CE6okQoTkm7QN8uIW0gV9mPmwFuqgzJxzlXAeYUh7jy1gyV8xlMhsqH6jbOYVXZaz-4BOGsXFnvIFioTHDVEMOqniCNVZwnG0d4jB70ZsjwZH8eo8_nbz8tL-urDxfvlm-u6o5zPtUdk9YJRy2RtHeMN0ZaEMqazjAK0koGXescJ7S31OKecuiYYpxgQUWLOTtGr3dzN3M3grMQpmQGvUl-NOlWR-P1v53gr_Uq_tSMciEZKwNe7gek-GOGPOnRZwvDYAKUfeiWN4ILLMndJBGkaSWhhXz-H7mOcwplD5qoYqLBWDSFOt1RNsWcE_SH1ATrrWRdJOutZL2TXF48-_uzB_631QK82AMmF399MsVS_sPxhraEbwPWO87nCW4OfZO-67IUyfX7L0vdfvyq2otzpbdRX-34blzfmfIXM5jMqQ</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Ward, Katherine N</creator><creator>Ohrling, Anu</creator><creator>Bryant, Naomi J</creator><creator>Bowley, Jennifer S</creator><creator>Ross, Euan M</creator><creator>Verity, Christopher M</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20120201</creationdate><title>Herpes simplex serious neurological disease in young children: incidence and long-term outcome</title><author>Ward, Katherine N ; Ohrling, Anu ; Bryant, Naomi J ; Bowley, Jennifer S ; Ross, Euan M ; Verity, Christopher M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b555t-b37cd6d2c172fd354a7ce68caba32e7c73eb9dd512fc2c0f25eb3835106269053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age Factors</topic><topic>Anatomy</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Cerebrospinal fluid</topic><topic>Child development</topic><topic>Children & youth</topic><topic>Convulsions & seizures</topic><topic>Developmental Delays</topic><topic>Encephalitis</topic><topic>Encephalitis, Herpes Simplex - complications</topic><topic>Encephalitis, Herpes Simplex - diagnosis</topic><topic>Encephalitis, Herpes Simplex - epidemiology</topic><topic>Ethics</topic><topic>Female</topic><topic>Fever</topic><topic>Fever - epidemiology</topic><topic>Fever - virology</topic><topic>General aspects</topic><topic>Herpes simplex virus</topic><topic>Herpes viruses</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Ireland - epidemiology</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Neonates</topic><topic>Nervous system</topic><topic>Neuroimaging</topic><topic>Prevention and actions</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Public health. 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Setting and patients A 3-year prospective survey of children aged 2–23 months in Britain and Ireland. Results 19 children had HSV central nervous system (CNS) infection; 13 aged 2–11 months had focal neuroimaging abnormalities and 11 long-term neurological sequelae. Of six aged 12–35 months, one had abnormal neuroimaging and three long-term neurological sequelae. 17 of the 19 had serious neurological disease. HSV CNS infection accounted for 23% of serious neurological disease in children aged 2–11 months and 4.5% in older children. Conclusions The incidence of HSV-induced serious neurological disease in the UK was estimated at 1 in 64 000/year in younger children and 1 in 230 000 in older children. HSV CNS infection has clinical effects ranging from frank encephalitis to severe illness with fever and convulsions to milder disease lacking encephalopathy.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>21685219</pmid><doi>10.1136/adc.2010.204677</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Anatomy Biological and medical sciences Central nervous system Cerebrospinal fluid Child development Children & youth Convulsions & seizures Developmental Delays Encephalitis Encephalitis, Herpes Simplex - complications Encephalitis, Herpes Simplex - diagnosis Encephalitis, Herpes Simplex - epidemiology Ethics Female Fever Fever - epidemiology Fever - virology General aspects Herpes simplex virus Herpes viruses Human viral diseases Humans Illnesses Incidence Infant Infections Infectious diseases Ireland - epidemiology Male Medical imaging Medical sciences Miscellaneous Neonates Nervous system Neuroimaging Prevention and actions Prognosis Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Questionnaires Seizures - epidemiology Seizures - virology Short Reports United Kingdom - epidemiology Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye |
| title | Herpes simplex serious neurological disease in young children: incidence and long-term outcome |
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