Herpes simplex serious neurological disease in young children: incidence and long-term outcome

Objective To determine the contribution of herpes simplex virus (HSV) to serious neurological disease. Setting and patients A 3-year prospective survey of children aged 2–23 months in Britain and Ireland. Results 19 children had HSV central nervous system (CNS) infection; 13 aged 2–11 months had foc...

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Veröffentlicht in:Archives of disease in childhood 2012-02, Vol.97 (2), p.162-165
Hauptverfasser: Ward, Katherine N, Ohrling, Anu, Bryant, Naomi J, Bowley, Jennifer S, Ross, Euan M, Verity, Christopher M
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Sprache:eng
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Zusammenfassung:Objective To determine the contribution of herpes simplex virus (HSV) to serious neurological disease. Setting and patients A 3-year prospective survey of children aged 2–23 months in Britain and Ireland. Results 19 children had HSV central nervous system (CNS) infection; 13 aged 2–11 months had focal neuroimaging abnormalities and 11 long-term neurological sequelae. Of six aged 12–35 months, one had abnormal neuroimaging and three long-term neurological sequelae. 17 of the 19 had serious neurological disease. HSV CNS infection accounted for 23% of serious neurological disease in children aged 2–11 months and 4.5% in older children. Conclusions The incidence of HSV-induced serious neurological disease in the UK was estimated at 1 in 64 000/year in younger children and 1 in 230 000 in older children. HSV CNS infection has clinical effects ranging from frank encephalitis to severe illness with fever and convulsions to milder disease lacking encephalopathy.
ISSN:0003-9888
1468-2044
1468-2044
DOI:10.1136/adc.2010.204677