Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder

Highlights ► PINK1 and Parkin are involved in regulating mitochondrial fission and fusion dynamics. ► PINK1 and Parkin are implicated in a process of autophagic removal of dysfunctional mitochondria called mitophagy. ► Mitochondrial dynamics and Mitophagy are thought to be required for the maintenan...

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Veröffentlicht in:	Current opinion in neurobiology 2011-12, Vol.21 (6), p.935-941
Hauptverfasser:	Imai, Yuzuru, Lu, Bingwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy - physiology Humans Mitochondria - genetics Mitochondria - pathology Mitochondrial Diseases - genetics Mitochondrial Diseases - pathology Neurology Parkinson Disease - genetics Parkinson Disease - physiopathology Protein Kinases - genetics Psychiatry Ubiquitin-Protein Ligases - genetics
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Beschreibung
Zusammenfassung:	Highlights ► PINK1 and Parkin are involved in regulating mitochondrial fission and fusion dynamics. ► PINK1 and Parkin are implicated in a process of autophagic removal of dysfunctional mitochondria called mitophagy. ► Mitochondrial dynamics and Mitophagy are thought to be required for the maintenance of a healthy mitochondrial network. ► The pathological relevance of mitophagy in PD etiology awaits further investigation.
ISSN:	0959-4388 1873-6882
DOI:	10.1016/j.conb.2011.10.016