Metabolic Connections during Apoptotic Cell Engulfment

Metabolic Connections during Apoptotic Cell Engulfment

Billions of cells die via apoptosis every day and are swiftly removed. When a phagocyte engulfs an apoptotic cell, it essentially doubles its cellular contents, raising the question of how a phagocyte may manage the excess metabolic load. This Minireview discusses phagocyte cellular metabolism, the...

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Veröffentlicht in:Cell 2011-12, Vol.147 (7), p.1442-1445
Hauptverfasser: Han, Claudia Z., Ravichandran, Kodi S.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Apoptosis
Cell Physiological Phenomena
digestion
Glucose - metabolism
Humans
Lipid Metabolism
metabolism
phagocytes
Phagocytes - metabolism
Phagocytosis
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Zusammenfassung:Billions of cells die via apoptosis every day and are swiftly removed. When a phagocyte engulfs an apoptotic cell, it essentially doubles its cellular contents, raising the question of how a phagocyte may manage the excess metabolic load. This Minireview discusses phagocyte cellular metabolism, the digestion of the ingested apoptotic cell, and the impact of these processes on engulfment.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2011.12.006