Enhanced expression of tissue inhibitor of metalloproteinases-4 gene in human osteoarthritic synovial membranes and its differential regulation by cytokines in chondrocytes
Tissue inhibitors of metalloproteinases (TIMPs) are multi-functional proteins with matrix metalloproteinases-inhibiting activities. We studied expression of anti-inflammatory, TIMP-4 gene in human joint tissues and its regulation by arthritis-associated cytokines. TIMP-4 RNA expression originating f...
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| Veröffentlicht in: | The open rheumatology journal 2011-11, Vol.5 (1), p.81-87 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Tissue inhibitors of metalloproteinases (TIMPs) are multi-functional proteins with matrix metalloproteinases-inhibiting activities. We studied expression of anti-inflammatory, TIMP-4 gene in human joint tissues and its regulation by arthritis-associated cytokines.
TIMP-4 RNA expression originating from synovial fibroblasts was significantly (2.4 fold; p |
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| ISSN: | 1874-3129 1874-3129 |
| DOI: | 10.2174/1874312901105010081 |