Computerized Neurocognitive Test Performance in Schizophrenia: A Lifespan Analysis

Objective Computerized neurocognitive batteries based on advanced behavioral neuroscience methods are increasingly used in large-scale clinical and genomic studies. Favorable construct validity in younger schizophrenia patients has been reported, but not in older patients. New variables afforded by computerized assessments were used to clarify age-associated cognitive impairment across the lifespan. Methods 624 patients with schizophrenia and 624 healthy comparison (HC) subjects age 16–75 completed a 1–2-hour computerized neurocognitive battery (CNB) that assessed abstraction and mental flexibility, attention, working memory, recognition memory (verbal, facial, spatial), language, visuospatial, and emotion processing. Linear mixed effects models tested for group differences in accuracy, response time, and efficiency scores. Contrasts were stratified by age. Results 91% of older (45+) and 94% of younger (