Sphingosine-kinase 1 and 2 contribute to oral sensitization and effector phase in a mouse model of food allergy

Highlights ► We investigated the impact of endogenous S1P level on food allergy. ► Tight junction integrity and allergen uptake by epithelial cells altered by S1P. ► Sphingosine-kinase deletion impaired food allergy in a mouse model.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2012-01, Vol.141 (2), p.210-219
Hauptverfasser:	Diesner, Susanne C, Olivera, Ana, Dillahunt, Sandra, Schultz, Cornelia, Watzlawek, Thomas, Förster-Waldl, Elisabeth, Pollak, Arnold, Jensen-Jarolim, Erika, Untersmayr, Eva, Rivera, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Allergic diseases Allergy and Immunology Anaphylaxis Animal models Animals Anti-ulcer medication Caco-2 Cells CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology Cell migration Cell Movement - genetics Chemokine CCL2 - genetics Chemokine CCL2 - immunology Chemokine CCL2 - metabolism Chymase Disease Models, Animal Enzymes Flow cytometry Food allergy Food hypersensitivity Food Hypersensitivity - diagnosis Food Hypersensitivity - genetics Food Hypersensitivity - immunology Gastric mucosa Gastric Mucosa - pathology Gene deletion Homeostasis Humans Immunoglobulin E Immunoglobulin E - biosynthesis Immunoglobulin E - blood Immunoglobulin E - genetics Immunoglobulin G Lymphocytes T Mast cells Mast Cells - immunology Mast Cells - metabolism Mast Cells - pathology Mice Mice, Inbred Strains Mice, Knockout Ovalbumin Ovalbumin - administration & dosage Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 11 - immunology Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism Sphingosine 1-phosphate Sphingosine kinase Spleen Up-Regulation
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Beschreibung
Zusammenfassung:	Highlights ► We investigated the impact of endogenous S1P level on food allergy. ► Tight junction integrity and allergen uptake by epithelial cells altered by S1P. ► Sphingosine-kinase deletion impaired food allergy in a mouse model.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2011.10.006