TOR in the immune system

Highlights ► mTOR regulates memory CD8 T cell differentiation. ► Differentiation into both effector and regulatory CD4 T cells is modulated by mTOR. ► mTOR has both stimulatory and inhibitory effects on DCs. ► Inhibiting mTOR has anti-aging effects and extends life span. ► Rapamycin rejuvenates func...

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Veröffentlicht in:	Current opinion in cell biology 2011-12, Vol.23 (6), p.707-715
Hauptverfasser:	Araki, Koichi, Ellebedy, Ali H, Ahmed, Rafi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Animals CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Cell Differentiation Dendritic Cells - immunology Humans Immunity, Innate Internal Medicine Signal Transduction T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology TOR Serine-Threonine Kinases - metabolism
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Beschreibung
Zusammenfassung:	Highlights ► mTOR regulates memory CD8 T cell differentiation. ► Differentiation into both effector and regulatory CD4 T cells is modulated by mTOR. ► mTOR has both stimulatory and inhibitory effects on DCs. ► Inhibiting mTOR has anti-aging effects and extends life span. ► Rapamycin rejuvenates functional ability of HSCs from aged mice.
ISSN:	0955-0674 1879-0410 1879-0410
DOI:	10.1016/j.ceb.2011.08.006