Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

Patients with COPD have increased peripheral airway resistance. In this study, increased peripheral airway resistance was strongly associated with a reduction in the number of terminal bronchioles rather than narrowing of airways. Direct measurement of the distribution of resistance in the lower res...

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Veröffentlicht in:	The New England journal of medicine 2011-10, Vol.365 (17), p.1567-1575
Hauptverfasser:	McDonough, John E, Yuan, Ren, Suzuki, Masaru, Seyednejad, Nazgol, Elliott, W. Mark, Sanchez, Pablo G, Wright, Alexander C, Gefter, Warren B, Litzky, Leslie, Coxson, Harvey O, Paré, Peter D, Sin, Don D, Pierce, Richard A, Woods, Jason C, McWilliams, Annette M, Mayo, John R, Lam, Stephen C, Cooper, Joel D, Hogg, James C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Airway Obstruction - diagnostic imaging Airway Obstruction - etiology Airway Resistance Biological and medical sciences Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease, asthma Computed tomography Emphysema Female Forced Expiratory Volume General aspects Humans Lung - diagnostic imaging Lung - pathology Lung diseases Lung transplantation Lungs Male Medical research Medical sciences Middle Aged Obstructive lung disease Pneumology Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary Disease, Chronic Obstructive - pathology Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Emphysema - diagnostic imaging Pulmonary Emphysema - etiology Respiratory tract Tomography, X-Ray Computed - methods
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Beschreibung
Zusammenfassung:	Patients with COPD have increased peripheral airway resistance. In this study, increased peripheral airway resistance was strongly associated with a reduction in the number of terminal bronchioles rather than narrowing of airways. Direct measurement of the distribution of resistance in the lower respiratory tract has established that small airways (i.e.,
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1106955