Exogenous Glutathione Protects Intestinal Epithelial Cells from Oxidative Injury

Exogenous Glutathione Protects Intestinal Epithelial Cells from Oxidative Injury

Exogenous GSH provided rat small-intestinal epithelial cells with significant protection against injury induced by t-butyl hydroperoxide or menadione. This protection was found to be dependent upon uptake of intact GSH. Uptake of GSH occurred by a Na+-dependent electrogenic system found in the basol...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1986-07, Vol.83 (13), p.4641-4645
Hauptverfasser: Lash, Lawrence H., Hagen, Tory M., Jones, Dean P.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
B lymphocytes
Biological and medical sciences
Biological Transport, Active
Cell Membrane - metabolism
Cell membranes
Cell physiology
Cell separation
Cell Survival - drug effects
Chemical hazards
Enterocytes
Epithelial cells
Fundamental and applied biological sciences. Psychology
Glutathione - metabolism
Glutathione - pharmacology
Hepatocytes
In Vitro Techniques
Intestinal Mucosa - drug effects
Intestinal Mucosa - ultrastructure
Miscellaneous
Molecular and cellular biology
Oxidation-Reduction
Peroxides - antagonists & inhibitors
Peroxides - toxicity
Physical trauma
Probenecid - pharmacology
Rats
Sodium - metabolism
Stem cells
tert-Butylhydroperoxide
Viability
Vitamin K - antagonists & inhibitors
Vitamin K - toxicity
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Zusammenfassung:Exogenous GSH provided rat small-intestinal epithelial cells with significant protection against injury induced by t-butyl hydroperoxide or menadione. This protection was found to be dependent upon uptake of intact GSH. Uptake of GSH occurred by a Na+-dependent electrogenic system found in the basolateral membrane. Thus, rat small-intestinal epithelial cells can utilize plasma GSH to support intracellular detoxication systems that function in protection against chemically induced injury.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.83.13.4641