Effects of granulocyte-colony-stimulating factor on Monosomy 7 aneuploidy in healthy hematopoietic stem cell and granulocyte donors

BACKGROUND: Reports of Monosomy 7 in patients receiving granulocyte–colony‐stimulating factor (G‐CSF) have raised concerns that this cytokine may promote genomic instability. However, there are no studies addressing whether repeated administration of G‐CSF produces Monosomy 7 aneuploidy in healthy d...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2012-03, Vol.52 (3), p.537-541
Hauptverfasser:	Olnes, Matthew J., Poon, Andrea, Miranda, Susan J., Pfannes, Loretta, Tucker, Zachary, Loeliger, Kelsey, Padilla-Nash, Hesed, Yau, Yu Ying, Ried, Thomas, Leitman, Susan F., Young, Neal S., Sloand, Elaine M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Aneuploidy Biological and medical sciences Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Bone marrow, stem cells transplantation. Graft versus host reaction Chromosome Deletion Chromosomes, Human, Pair 7 - drug effects Dexamethasone - administration & dosage Genomic Instability - drug effects Glucocorticoids - administration & dosage Granulocyte Colony-Stimulating Factor - administration & dosage Granulocytes - drug effects Granulocytes - physiology Granulocytes - transplantation Hematopoietic Stem Cell Mobilization - adverse effects Hematopoietic Stem Cell Mobilization - methods Hematopoietic Stem Cell Mobilization - standards Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - physiology Humans Medical sciences Tissue Donors Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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