Angiotensin-Converting Enzyme Genotype and Peripheral Arterial Disease in Diabetic Patients

We investigated the effect of traditional risk factors (hypertension, dyslipidemia and smoking) on the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and peripheral arterial disease (PAD) in 945 (454 men and 491 women) Taiwanese type 2 diabetic pat...

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Veröffentlicht in:	Experimental diabetes research 2012-01, Vol.2012 (2012), p.1-7
Hauptverfasser:	Tseng, Chin-Hsiao, Tseng, Farn-Hsuan, Chong, Choon-Khim, Tseng, Ching-Ping, Cheng, Ju-Chien
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Asian Continental Ancestry Group - genetics Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics Diabetic Angiopathies - epidemiology Diabetic Angiopathies - ethnology Diabetic Angiopathies - genetics Female Genetic Predisposition to Disease Genotype Humans INDEL Mutation - physiology Male Middle Aged Peptidyl-Dipeptidase A - genetics Peripheral Arterial Disease - epidemiology Peripheral Arterial Disease - ethnology Peripheral Arterial Disease - etiology Peripheral Arterial Disease - genetics Polymorphism, Genetic - physiology Risk Factors Taiwan - epidemiology
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Zusammenfassung:	We investigated the effect of traditional risk factors (hypertension, dyslipidemia and smoking) on the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and peripheral arterial disease (PAD) in 945 (454 men and 491 women) Taiwanese type 2 diabetic patients with a mean age of 63.5 (SD: 11.4) years. Among them, 81 (31 men and 50 women) had PAD (ankle-brachial index
ISSN:	1687-5214 1687-5303
DOI:	10.1155/2012/698695