The BCL-2 Family Reunion

B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular p...

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Veröffentlicht in:	Molecular cell 2010-02, Vol.37 (3), p.299-310
Hauptverfasser:	Chipuk, Jerry E., Moldoveanu, Tudor, Llambi, Fabien, Parsons, Melissa J., Green, Douglas R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Apoptosis Autophagy Endoplasmic Reticulum - metabolism Mitochondrial Membranes - metabolism Mitochondrial Membranes - ultrastructure Models, Biological Molecular Sequence Data Multigene Family Permeability Proto-Oncogene Proteins c-bcl-2 - chemistry Proto-Oncogene Proteins c-bcl-2 - metabolism Proto-Oncogene Proteins c-bcl-2 - physiology Sequence Alignment Signal Transduction
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Beschreibung
Zusammenfassung:	B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions.
ISSN:	1097-2765 1097-4164 1097-4164
DOI:	10.1016/j.molcel.2010.01.025