The Spectrum of Kidney Involvement in Lymphoma: A Case Report and Review of the Literature

Kidney involvement is an under-recognized complication of both Hodgkin and non-Hodgkin lymphoma. The diversity of lymphoma-related renal manifestations makes diagnosis difficult. Although abrupt worsening of kidney function may be the first sign of malignant disease, renal effects can be subtle or e...

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Veröffentlicht in:	American journal of kidney diseases 2010-12, Vol.56 (6), p.1191-1196
Hauptverfasser:	Cohen, Lisa J., MD, Rennke, Helmut G., MD, Laubach, Jacob P., MD, Humphreys, Benjamin D., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibodies, Monoclonal, Murine-Derived - therapeutic use Antineoplastic Agents - therapeutic use Biological and medical sciences Boronic Acids - therapeutic use Bortezomib Dexamethasone - therapeutic use Drug Therapy, Combination Hematologic and hematopoietic diseases Hodgkin lymphoma Humans Kidney - pathology Kidney - physiopathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Non-Hodgkin - complications Lymphoma, Non-Hodgkin - drug therapy Lymphoma, Non-Hodgkin - physiopathology Male Medical sciences Nephrology Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure nephrotic non-Hodgkin lymphoma Prognosis Pyrazines - therapeutic use Renal failure Renal Insufficiency - diagnosis Renal Insufficiency - etiology Renal Insufficiency - physiopathology Rituximab Treatment Outcome
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Zusammenfassung:	Kidney involvement is an under-recognized complication of both Hodgkin and non-Hodgkin lymphoma. The diversity of lymphoma-related renal manifestations makes diagnosis difficult. Although abrupt worsening of kidney function may be the first sign of malignant disease, renal effects can be subtle or even silent. The causes of renal involvement similarly are varied. We discuss a case of non-Hodgkin lymphoma and associated kidney failure from several distinct malignancy-related mechanisms and review the spectrum of lymphoma-related kidney involvement.
ISSN:	0272-6386 1523-6838
DOI:	10.1053/j.ajkd.2010.07.009