Contributions of mature granule cells to structural plasticity in temporal lobe epilepsy

Abstract During the development of epilepsy in adult animals, newly generated granule cells integrate abnormally into the hippocampus. These new cells migrate to ectopic locations in the hilus, develop aberrant basal dendrites, contribute to mossy fiber sprouting, and exhibit changes in apical dendr...

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Veröffentlicht in:	Neuroscience 2011-12, Vol.197, p.348-357
Hauptverfasser:	Santos, V.R, de Castro, O.W, Pun, R.Y.K, Hester, M.S, Murphy, B.L, Loepke, A.W, Garcia-Cairasco, N, Danzer, S.C
Format:	Artikel
Sprache:	eng
Schlagworte:	adult neurogenesis Animals basal dendrite Biological and medical sciences dendritic spine Dendritic Spines - pathology Disease Models, Animal Epilepsy, Temporal Lobe - pathology Fundamental and applied biological sciences. Psychology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy hilar ectopic granule cell Hippocampus - pathology Immunohistochemistry Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Confocal mossy fiber sprouting Nervous system (semeiology, syndromes) Neurology status epilepticus Vertebrates: nervous system and sense organs
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