P5 - Evaluation of Immunological Reactivity to Metal Components in Patients with Prosthesis Device

In recent years, the development of innovative biomaterials and surgical techniques has led to a progressive increase in joint replacement arthroplasty procedures. It is well known that all implant metals, in contact with biological fluids, undergo electrochemical and mechanical corrosion, releasing metallic particles that may induce toxic responses and local or systemic inflammatory reactions. Several studies have demonstrated a possible relationship between particulate wear debris and symptoms of dermatitis and urticaria, but there is no evidence of a direct correlation between wear severity and immune response. Published results show that the immune reaction changes with individual immunomodulatory status. The aim of this study was to analyse the proliferative response in the presence of proper stimuli, and to identify possible modifications in the production of a wide range of cytokines, as potential biological markers for early diagnosis of aseptic loosening.