Determinants of Blood Pressure Response to Low‐Salt Intake in a Healthy Adult Population

J Clin Hypertens (Greenwich). 2011;13:795–800. ©2011 Wiley Periodicals, Inc. Although the beneficial effects of lowering salt intake in hypertensive patients are widely appreciated, the impact of promoting dietary salt restriction for blood pressure (BP) reduction at the population level remains controversial. The authors used 24‐hour ambulatory BP monitoring to characterize the determinants of systolic BP (SBP) response to low‐salt intake in a large, relatively healthy Amish population. Patients received a high‐ and low‐sodium diet for 6 days each, separated by a 6‐ to 14‐day washout period. Variance component analysis was used to assess the association of several variables with SBP response to low‐salt diet. Mean SBP was 0.7±5.8 mm Hg and 1.3±6.1 mm Hg lower on the low‐salt compared with the high‐salt diet during daytime (P=.008) and nighttime (P