Progesterone receptor polymorphisms and clinical response to 17-alpha-hydroxyprogesterone caproate

Objective Seventeen-alpha-hydroxyprogesterone caproate (17-OHPC) reduces recurrent preterm birth (PTB). We hypothesized that single nucleotide polymorphisms in the human progesterone receptor (PGR) affect response to 17-OHPC in the prevention of recurrent PTB. Study Design We conducted secondary ana...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2011-08, Vol.205 (2), p.135.e1-135.e9
Hauptverfasser:	Manuck, Tracy A., MD, Lai, Yinglei, PhD, Meis, Paul J., MD, Dombrowski, Mitchell P., MD, Sibai, Baha, MD, Spong, Catherine Y., MD, Rouse, Dwight J., MD, Durnwald, Celeste P., MD, Caritis, Steve N., MD, Wapner, Ronald J., MD, Mercer, Brian M., MD, Ramin, Susan M., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	17 alpha-Hydroxyprogesterone Caproate Biological and medical sciences Double-Blind Method Female Gene Expression Regulation, Developmental genetic polymorphisms Gestational Age Gynecology. Andrology. Obstetrics Humans Hydroxyprogesterones - administration & dosage Infant, Newborn Infant, Premature Logistic Models Medical sciences Multivariate Analysis Obstetrics and Gynecology Polymorphism, Single Nucleotide - drug effects Polymorphism, Single Nucleotide - genetics Pregnancy Pregnancy Outcome Premature Birth - drug therapy Premature Birth - genetics Premature Birth - prevention & control progesterone receptor Prospective Studies Receptors, Progesterone - drug effects Receptors, Progesterone - genetics recurrent preterm birth Reference Values Risk Assessment Secondary Prevention Treatment Outcome
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Zusammenfassung:	Objective Seventeen-alpha-hydroxyprogesterone caproate (17-OHPC) reduces recurrent preterm birth (PTB). We hypothesized that single nucleotide polymorphisms in the human progesterone receptor (PGR) affect response to 17-OHPC in the prevention of recurrent PTB. Study Design We conducted secondary analysis of a study of 17-OHPC vs placebo for recurrent PTB prevention. Twenty PGR gene single nucleotide polymorphisms were studied. Multivariable logistic regression assessed for an interaction between PGR genotype and treatment status in modulating the risk of recurrent PTB. Results A total of 380 women were included; 253 (66.6%) received 17-OHPC and 127 (33.4%) received placebo. In all, 61.1% of women were African American. Multivariable logistic regression demonstrated significant treatment-genotype interactions (either a beneficial or harmful treatment response) for African Americans delivering
ISSN:	0002-9378 1097-6868 1097-6868
DOI:	10.1016/j.ajog.2011.03.048