Developmental lead exposure causes startle response deficits in zebrafish

Developmental lead exposure causes startle response deficits in zebrafish

► Time to respond, maximum velocity and escape swim duration are affected by low developmental Pb 2+. ► Escape swim at chamber center for embryo Pb 2+-exposure larvae; control larvae swim at periphery. ► Low developmental Pb 2+ reduces response rate to visual stimuli in adult zebrafish. Lead (Pb 2+)...

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Veröffentlicht in:Aquatic toxicology 2011-10, Vol.105 (3), p.600-608
Hauptverfasser: Rice, Clinton, Ghorai, Jugal K., Zalewski, Kathryn, Weber, Daniel N.
Format: Artikel
Sprache:eng
Schlagworte:
Animal, plant and microbial ecology
Animals
Applied ecology
Behavior
Biological and medical sciences
Danio rerio
Dose-Response Relationship, Drug
Ecotoxicology, biological effects of pollution
Embryo, Nonmammalian
Escape Reaction - drug effects
Freshwater
Fundamental and applied biological sciences. Psychology
General aspects
Larva - drug effects
Larva - physiology
Lead
Lead - pharmacokinetics
Lead - toxicity
Mechanosensory
Reflex, Startle - drug effects
Startle response
Time Factors
Toxicity Tests, Acute
Visual
Water Pollutants, Chemical - pharmacokinetics
Water Pollutants, Chemical - toxicity
Zebrafish
Zebrafish - embryology
Zebrafish - physiology
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Zusammenfassung:► Time to respond, maximum velocity and escape swim duration are affected by low developmental Pb 2+. ► Escape swim at chamber center for embryo Pb 2+-exposure larvae; control larvae swim at periphery. ► Low developmental Pb 2+ reduces response rate to visual stimuli in adult zebrafish. Lead (Pb 2+) exposure continues to be an important concern for fish populations. Research is required to assess the long-term behavioral effects of low-level concentrations of Pb 2+ and the physiological mechanisms that control those behaviors. Newly fertilized zebrafish embryos (
ISSN:0166-445X
1879-1514
DOI:10.1016/j.aquatox.2011.08.014