Class D OXA-48 carbapenemase in multidrug-resistant enterobacteria, senegal

Class D OXA β-lactamases are characterized as penicillinases that can hydrolyze oxacillin and cloxacillin and are poorly inhibited by clavulanic acid and EDTA. OXA-48 is one of the few members of this family to possess notable carbapenem-hydrolyzing activity. First described in 2004 in Turkey, OXA-4...

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Veröffentlicht in:	Emerging infectious diseases 2011-01, Vol.17 (1), p.143-144
Hauptverfasser:	Moquet, Olivier, Bouchiat, Coralie, Kinana, Alfred, Seck, Abdoulaye, Arouna, Omar, Bercion, Raymond, Breurec, Sebastien, Garin, Benoit
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Bacteriology Beta lactamases Class D OXA-48 Carbapenemase in Multidrug-Resistant Enterobacteria, Senegal Enterobacter Enterobacteriaceae Genetic aspects Health aspects Human health and pathology Infectious diseases Letters to the Editor Life Sciences Microbiology and Parasitology
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Beschreibung
Zusammenfassung:	Class D OXA β-lactamases are characterized as penicillinases that can hydrolyze oxacillin and cloxacillin and are poorly inhibited by clavulanic acid and EDTA. OXA-48 is one of the few members of this family to possess notable carbapenem-hydrolyzing activity. First described in 2004 in Turkey, OXA-48 has recently started to spread in Europe and the Middle East. We report the recent emergence of the plasmid-encoded bla OXA-48 gene in multidrug-resistant Enterobacteriaceae recovered from patients in Dakar, Senegal, in hospitals and in the community.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1701.100224