CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications

CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications

Abstract C–X–C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10 kDa (IP-10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family. CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis. Alterations in CXCL10 ex...

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Veröffentlicht in:Cytokine & growth factor reviews 2011-06, Vol.22 (3), p.121-130
Hauptverfasser: Liu, Mingli, Guo, Shanchun, Hibbert, Jacqueline M, Jain, Vidhan, Singh, Neeru, Wilson, Nana O, Stiles, Jonathan K
Format: Artikel
Sprache:eng
Schlagworte:
Advanced Basic Science
Angiogenesis Inhibitors - immunology
Angiogenesis Inhibitors - metabolism
Animals
Apoptosis - immunology
Biomarkers - metabolism
Chemokine
Chemokine CXCL10 - immunology
Chemokine CXCL10 - metabolism
Chemotaxis - immunology
CXCL10
CXCR3
Gene Expression Regulation - immunology
Humans
Infections - immunology
Infections - metabolism
Infections - pathology
Infections - therapy
Infectious diseases
Inflammation - immunology
Inflammation - metabolism
Inflammation - pathology
Receptors, CXCR3 - immunology
Receptors, CXCR3 - metabolism
Severity of Illness Index
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Zusammenfassung:Abstract C–X–C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10 kDa (IP-10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family. CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis. Alterations in CXCL10 expression levels have been associated with inflammatory diseases including infectious diseases, immune dysfunction and tumor development. CXCL10 is also recognized as a biomarker that predicts severity of various diseases. A review of the emerging role of CXCL10 in pathogenesis of infectious diseases revealed diverse roles of CXCL10 in disease initiation and progression. The potential utilization of CXCL10 as a therapeutic target for infectious diseases is discussed.
ISSN:1359-6101
1879-0305
DOI:10.1016/j.cytogfr.2011.06.001