Low 25-Hydroxyvitamin D Levels and Mortality in Non–Dialysis-Dependent CKD

Background Low 25-hydroxyvitamin D (25[OH]D) levels are common in patients with non–dialysis-dependent chronic kidney disease (CKD). The associations between low 25(OH)D levels and mortality in non–dialysis-dependent patients with CKD are unclear. Study Design Retrospective cohort study. Setting &am...

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Veröffentlicht in:	American journal of kidney diseases 2011-10, Vol.58 (4), p.536-543
Hauptverfasser:	Navaneethan, Sankar D., MD, MPH, Schold, Jesse D., PhD, Arrigain, Susana, MA, Jolly, Stacey E., MD, MS, Jain, Anil, MD, Schreiber, Martin J., MD, Simon, James F., MD, Srinivas, Titte R., MD, Nally, Joseph V., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans - statistics & numerical data Aged Aged, 80 and over Biological and medical sciences Body Mass Index Cause of Death Chi-Square Distribution Chronic Disease Chronic kidney disease Comorbidity Diabetic Nephropathies - blood Diabetic Nephropathies - mortality Female Humans Kaplan-Meier Estimate Kidney Diseases - blood Kidney Diseases - mortality Kidneys Male Medical sciences Metabolic diseases Middle Aged mortality Nephrology Nephrology. Urinary tract diseases Obesity Prevalence Proportional Hazards Models Registries Seasons United States - epidemiology Urinary system involvement in other diseases. Miscellaneous Vitamin D - analogs & derivatives Vitamin D - blood vitamin D deficiency Vitamin D Deficiency - epidemiology
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Zusammenfassung:	Background Low 25-hydroxyvitamin D (25[OH]D) levels are common in patients with non–dialysis-dependent chronic kidney disease (CKD). The associations between low 25(OH)D levels and mortality in non–dialysis-dependent patients with CKD are unclear. Study Design Retrospective cohort study. Setting & Participants Patients with stages 3-4 CKD (estimated glomerular filtration rate, 15-59 mL/min/1.73 m2 ; n = 12,673) who had 25(OH)D levels measured after the diagnosis of CKD in the Cleveland Clinic Health System. Predictor 25(OH)D levels categorized into 3 groups:
ISSN:	0272-6386 1523-6838
DOI:	10.1053/j.ajkd.2011.04.028