Therapeutic targeting of Id2 reduces growth of human colorectal carcinoma in the murine liver

During development inhibitor of DNA-bind-2 (Id2) regulates proliferation and differentiation. Id2 expression has been detected in cancer cells, yet its cellular function and validity as a therapeutic target remains largely unknown. Immunohistochemical analysis of colorectal cancer (CRC) specimens re...

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Veröffentlicht in:	Oncogene 2008-12, Vol.27 (57), p.7192-7200
Hauptverfasser:	Gray, M J, Dallas, N A, Van Buren, G, Xia, L, Yang, A D, Somcio, R J, Gaur, P, Mangala, L S, Vivas-Mejia, P E, Fan, F, Sanguino, A M, Gallick, G E, Lopez-Berestein, G, Sood, A K, Ellis, L M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Apoptosis Apoptosis - physiology Autoradiography BIM protein Biological and medical sciences Blotting, Western Caspase-7 Causes of Cell Biology Cell cycle Cell Line, Tumor Cell physiology Cell Proliferation Cell survival Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cyclin D1 Deoxyribonucleic acid DNA DNA binding proteins Flow Cytometry Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene expression Genetic aspects Genetics Health aspects Human Genetics Humans Immunohistochemistry Immunoprecipitation Inhibitor of Differentiation Protein 2 - genetics Inhibitor of Differentiation Protein 2 - metabolism Internal Medicine Lecithin Liver Liver Neoplasms - secondary Medical sciences Medicine Medicine & Public Health Metastases Metastasis Mice Molecular and cellular biology Mucosa Oncology original-article Phosphatidylcholine Physiological aspects Regulatory proteins Ribose RNA, Small Interfering Rodents Signal Transduction - physiology siRNA Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Therapeutic applications Therapeutic targets Tumors Up-Regulation Xenograft Model Antitumor Assays
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Zusammenfassung:	During development inhibitor of DNA-bind-2 (Id2) regulates proliferation and differentiation. Id2 expression has been detected in cancer cells, yet its cellular function and validity as a therapeutic target remains largely unknown. Immunohistochemical analysis of colorectal cancer (CRC) specimens revealed that Id2 was undetectable in normal colonic mucosa, but occurs in 40% of primary tumors and in most CRC liver metastases ( P
ISSN:	0950-9232 1476-5594
DOI:	10.1038/onc.2008.356