Characterization of novel Pannexin 1 isoforms from rat pituitary cells and their association with ATP-gated P2X channels
Highlights ► Two novel Pannexin 1 splicing isoforms were identified from rat pituitary cells. ► The isoforms show different cellular distribution pattern than wild-type Pannexin 1. ► Wild-type Pannexin 1 and its isoforms can form homomeric and heteromeric complexes. ► The two novel isoforms can atte...
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| Veröffentlicht in: | General and comparative endocrinology 2011-11, Vol.174 (2), p.202-210 |
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| container_title | General and comparative endocrinology |
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| creator | Li, Shuo Tomić, Melanija Stojilkovic, Stanko S |
| description | Highlights ► Two novel Pannexin 1 splicing isoforms were identified from rat pituitary cells. ► The isoforms show different cellular distribution pattern than wild-type Pannexin 1. ► Wild-type Pannexin 1 and its isoforms can form homomeric and heteromeric complexes. ► The two novel isoforms can attenuate the wild-type Pannexin 1-mediated ATP release. ► All Pannexin 1 isoforms can interact with P2X channels expressed in pituitary cells. |
| doi_str_mv | 10.1016/j.ygcen.2011.08.019 |
| format | Article |
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Tomić, Melanija ; Stojilkovic, Stanko S</creator><creatorcontrib>Li, Shuo ; Tomić, Melanija ; Stojilkovic, Stanko S</creatorcontrib><description>Highlights ► Two novel Pannexin 1 splicing isoforms were identified from rat pituitary cells. ► The isoforms show different cellular distribution pattern than wild-type Pannexin 1. ► Wild-type Pannexin 1 and its isoforms can form homomeric and heteromeric complexes. ► The two novel isoforms can attenuate the wild-type Pannexin 1-mediated ATP release. ► All Pannexin 1 isoforms can interact with P2X channels expressed in pituitary cells.</description><identifier>ISSN: 0016-6480</identifier><identifier>EISSN: 1095-6840</identifier><identifier>DOI: 10.1016/j.ygcen.2011.08.019</identifier><identifier>PMID: 21907716</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>adenosine triphosphate ; Alternative splicing ; Animals ; Anterior pituitary ; ATP ; ATP release ; AtT-20 cells ; Biotin ; Blotting, Western ; Cell Line ; Cells, Cultured ; Confocal microscopy ; connexins ; Connexins - metabolism ; endocrinology ; Endocrinology & Metabolism ; Exons ; Female ; Gap junctions ; Humans ; Immunoprecipitation ; microscopy ; Nerve Tissue Proteins - metabolism ; Pannexins ; Pituitary ; pituitary gland ; Pituitary Gland - metabolism ; plasma membrane ; Plasma membranes ; Protein Binding ; Purine P2X receptors ; Purinergic P2X receptors ; Rats ; Rats, Sprague-Dawley ; Receptors, Purinergic P2X - metabolism</subject><ispartof>General and comparative endocrinology, 2011-11, Vol.174 (2), p.202-210</ispartof><rights>2011</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-4a3443a840fab9cc1bd62924a0a7f81a5a40191f9f07e1f13df391e5bc606f003</citedby><cites>FETCH-LOGICAL-c570t-4a3443a840fab9cc1bd62924a0a7f81a5a40191f9f07e1f13df391e5bc606f003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0016648011003340$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21907716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Shuo</creatorcontrib><creatorcontrib>Tomić, Melanija</creatorcontrib><creatorcontrib>Stojilkovic, Stanko S</creatorcontrib><title>Characterization of novel Pannexin 1 isoforms from rat pituitary cells and their association with ATP-gated P2X channels</title><title>General and comparative endocrinology</title><addtitle>Gen Comp Endocrinol</addtitle><description>Highlights ► Two novel Pannexin 1 splicing isoforms were identified from rat pituitary cells. ► The isoforms show different cellular distribution pattern than wild-type Pannexin 1. ► Wild-type Pannexin 1 and its isoforms can form homomeric and heteromeric complexes. ► The two novel isoforms can attenuate the wild-type Pannexin 1-mediated ATP release. ► All Pannexin 1 isoforms can interact with P2X channels expressed in pituitary cells.</description><subject>adenosine triphosphate</subject><subject>Alternative splicing</subject><subject>Animals</subject><subject>Anterior pituitary</subject><subject>ATP</subject><subject>ATP release</subject><subject>AtT-20 cells</subject><subject>Biotin</subject><subject>Blotting, Western</subject><subject>Cell Line</subject><subject>Cells, Cultured</subject><subject>Confocal microscopy</subject><subject>connexins</subject><subject>Connexins - metabolism</subject><subject>endocrinology</subject><subject>Endocrinology & Metabolism</subject><subject>Exons</subject><subject>Female</subject><subject>Gap junctions</subject><subject>Humans</subject><subject>Immunoprecipitation</subject><subject>microscopy</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Pannexins</subject><subject>Pituitary</subject><subject>pituitary gland</subject><subject>Pituitary Gland - metabolism</subject><subject>plasma membrane</subject><subject>Plasma membranes</subject><subject>Protein Binding</subject><subject>Purine P2X receptors</subject><subject>Purinergic P2X receptors</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Purinergic P2X - metabolism</subject><issn>0016-6480</issn><issn>1095-6840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1vEzEQhlcIREPhFyCBb3DZMLPezwOVqogvqRKR2krcrInXThw2dmo7oeHX4yWlAg5w2sM-82peP5NlzxGmCFi_WU8PS6nstADEKbRTwO5BNkHoqrxuS3iYTSBheV22cJI9CWENABWv8XF2UmAHTYP1JLudrciTjMqb7xSNs8xpZt1eDWxO1qpbYxkyE5x2fhOY9m7DPEW2NXFnIvkDk2oYAiPbs7hSxjMKwUlzzPpm4oqdX83zJUXVs3nxhcnVGDuEp9kjTUNQz-6-p9n1-3dXs4_5xecPn2bnF7msGoh5SbwsOaU-mhadlLjo66IrSgJqdItUUZl6o-40NAo18l7zDlW1kDXUGoCfZmfH3O1usVF9erDoaRBbbzZpe-HIiD__WLMSS7cXHLuqbcoU8OouwLubnQpRbEwYS5NVbhdE27VtWRRNkcjX_ySTGl5Wbdc0CeVHVHoXglf6fiEEMdoVa_HTrhjtCmhFapmmXvze5X7ml84EvDwCmpygpTdBXF-mhCpdAm9aHNu8PRJJgdob5UWQRlmpeuOVjKJ35j8rnP01LwdjjaThqzqosHY7b5NOgSIUAsTleILjBSImF7wE_gOp3tbb</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Li, Shuo</creator><creator>Tomić, Melanija</creator><creator>Stojilkovic, Stanko S</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111101</creationdate><title>Characterization of novel Pannexin 1 isoforms from rat pituitary cells and their association with ATP-gated P2X channels</title><author>Li, Shuo ; Tomić, Melanija ; Stojilkovic, Stanko S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-4a3443a840fab9cc1bd62924a0a7f81a5a40191f9f07e1f13df391e5bc606f003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>adenosine triphosphate</topic><topic>Alternative splicing</topic><topic>Animals</topic><topic>Anterior pituitary</topic><topic>ATP</topic><topic>ATP release</topic><topic>AtT-20 cells</topic><topic>Biotin</topic><topic>Blotting, Western</topic><topic>Cell Line</topic><topic>Cells, Cultured</topic><topic>Confocal microscopy</topic><topic>connexins</topic><topic>Connexins - metabolism</topic><topic>endocrinology</topic><topic>Endocrinology & Metabolism</topic><topic>Exons</topic><topic>Female</topic><topic>Gap junctions</topic><topic>Humans</topic><topic>Immunoprecipitation</topic><topic>microscopy</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Pannexins</topic><topic>Pituitary</topic><topic>pituitary gland</topic><topic>Pituitary Gland - metabolism</topic><topic>plasma membrane</topic><topic>Plasma membranes</topic><topic>Protein Binding</topic><topic>Purine P2X receptors</topic><topic>Purinergic P2X receptors</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Purinergic P2X - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Shuo</creatorcontrib><creatorcontrib>Tomić, Melanija</creatorcontrib><creatorcontrib>Stojilkovic, Stanko S</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>General and comparative endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Shuo</au><au>Tomić, Melanija</au><au>Stojilkovic, Stanko S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of novel Pannexin 1 isoforms from rat pituitary cells and their association with ATP-gated P2X channels</atitle><jtitle>General and comparative endocrinology</jtitle><addtitle>Gen Comp Endocrinol</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>174</volume><issue>2</issue><spage>202</spage><epage>210</epage><pages>202-210</pages><issn>0016-6480</issn><eissn>1095-6840</eissn><abstract>Highlights ► Two novel Pannexin 1 splicing isoforms were identified from rat pituitary cells. ► The isoforms show different cellular distribution pattern than wild-type Pannexin 1. ► Wild-type Pannexin 1 and its isoforms can form homomeric and heteromeric complexes. ► The two novel isoforms can attenuate the wild-type Pannexin 1-mediated ATP release. ► All Pannexin 1 isoforms can interact with P2X channels expressed in pituitary cells.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21907716</pmid><doi>10.1016/j.ygcen.2011.08.019</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | General and comparative endocrinology, 2011-11, Vol.174 (2), p.202-210 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | adenosine triphosphate Alternative splicing Animals Anterior pituitary ATP ATP release AtT-20 cells Biotin Blotting, Western Cell Line Cells, Cultured Confocal microscopy connexins Connexins - metabolism endocrinology Endocrinology & Metabolism Exons Female Gap junctions Humans Immunoprecipitation microscopy Nerve Tissue Proteins - metabolism Pannexins Pituitary pituitary gland Pituitary Gland - metabolism plasma membrane Plasma membranes Protein Binding Purine P2X receptors Purinergic P2X receptors Rats Rats, Sprague-Dawley Receptors, Purinergic P2X - metabolism |
| title | Characterization of novel Pannexin 1 isoforms from rat pituitary cells and their association with ATP-gated P2X channels |
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