Characterization of novel Pannexin 1 isoforms from rat pituitary cells and their association with ATP-gated P2X channels

Highlights ► Two novel Pannexin 1 splicing isoforms were identified from rat pituitary cells. ► The isoforms show different cellular distribution pattern than wild-type Pannexin 1. ► Wild-type Pannexin 1 and its isoforms can form homomeric and heteromeric complexes. ► The two novel isoforms can atte...

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Veröffentlicht in:	General and comparative endocrinology 2011-11, Vol.174 (2), p.202-210
Hauptverfasser:	Li, Shuo, Tomić, Melanija, Stojilkovic, Stanko S
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine triphosphate Alternative splicing Animals Anterior pituitary ATP ATP release AtT-20 cells Biotin Blotting, Western Cell Line Cells, Cultured Confocal microscopy connexins Connexins - metabolism endocrinology Endocrinology & Metabolism Exons Female Gap junctions Humans Immunoprecipitation microscopy Nerve Tissue Proteins - metabolism Pannexins Pituitary pituitary gland Pituitary Gland - metabolism plasma membrane Plasma membranes Protein Binding Purine P2X receptors Purinergic P2X receptors Rats Rats, Sprague-Dawley Receptors, Purinergic P2X - metabolism
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Zusammenfassung:	Highlights ► Two novel Pannexin 1 splicing isoforms were identified from rat pituitary cells. ► The isoforms show different cellular distribution pattern than wild-type Pannexin 1. ► Wild-type Pannexin 1 and its isoforms can form homomeric and heteromeric complexes. ► The two novel isoforms can attenuate the wild-type Pannexin 1-mediated ATP release. ► All Pannexin 1 isoforms can interact with P2X channels expressed in pituitary cells.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2011.08.019