Cellular and molecular effects of thiazolidinediones on bone cells: a review

Thiazolidinediones represent a class of molecules used in the treatment of type 2 diabetes mellitus. Despite interesting effects in lowering blood glucose and HbA1c levels durably, an augmentation of the fracture risk in women has emerged in the past years. This review is providing the readers with...

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Veröffentlicht in:International journal of biochemistry and molecular biology 2011, Vol.2 (3), p.240-246
Hauptverfasser: Mabilleau, Guillaume, Chappard, Daniel, Baslé, Michel F
Format: Artikel
Sprache:eng
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Zusammenfassung:Thiazolidinediones represent a class of molecules used in the treatment of type 2 diabetes mellitus. Despite interesting effects in lowering blood glucose and HbA1c levels durably, an augmentation of the fracture risk in women has emerged in the past years. This review is providing the readers with information about the cellular and molecular mechanisms involved in bone and bone cells in response to these drugs.
ISSN:2152-4114
2152-4114