The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC): Results from phase I and scientific opportunities in phase II

Background Genetically triggered thoracic aortic conditions (GenTACs) represent an important problem for patients and their families. Accordingly, the National Heart, Lung, and Blood Institute established the first phase of its national GenTAC Registry in 2006. Enrollment and Diagnoses Between 2007...

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Veröffentlicht in:	The American heart journal 2011-10, Vol.162 (4), p.627-632.e1
Hauptverfasser:	Kroner, Barbara L., PhD, Tolunay, H. Eser, PhD, Basson, Craig T., MD, PhD, Pyeritz, Reed E., MD, PhD, Holmes, Kathryn W., MD, Maslen, Cheryl L., PhD, Milewicz, Dianna M., MD, PhD, LeMaire, Scott A., MD, Hendershot, Tabitha, Desvigne-Nickens, Patrice, MD, Devereux, Richard B., MD, Dietz, Harry C., MD, PhD, Song, Howard K., MD, PhD, Ringer, Danny, Mitchell, Megan, MPH, Weinsaft, Jonathan W., MD, Ravekes, William, MD, Menashe, Victor, MD, Eagle, Kim A., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aneurysms Aortic Aneurysm, Thoracic - genetics Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Cardiovascular Diseases - genetics Child Child, Preschool Diseases of the aorta Drug therapy Female Humans Male Medical sciences Middle Aged Mutation Registries Studies Young Adult
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Beschreibung
Zusammenfassung:	Background Genetically triggered thoracic aortic conditions (GenTACs) represent an important problem for patients and their families. Accordingly, the National Heart, Lung, and Blood Institute established the first phase of its national GenTAC Registry in 2006. Enrollment and Diagnoses Between 2007 and 2010, 6 enrolling centers established the GenTAC I Registry consisting of 2,046 patients (Marfan syndrome 576 [28.2%], bicuspid aortic valve disease 504 [24.6%], aneurysm or dissection age
ISSN:	0002-8703 1097-6744 1097-6744
DOI:	10.1016/j.ahj.2011.07.002