A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations

This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration, and oxidation to give collections of quinoxalines in good to e...

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Veröffentlicht in:	Tetrahedron letters 2011-09, Vol.52 (38), p.4821-4823
Hauptverfasser:	Ayaz, Muhammad, Dietrich, Justin, Hulme, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	chemical structure Chemistry Collection Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Intramolecular cyclization Libraries Methodology Microwave microwave treatment Microwaves Multicomponent reaction Nucleophiles Organic chemistry Oxidation Petasis reaction Preparations and properties Quinoxaline Quinoxalines Tetrahedrons
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Beschreibung
Zusammenfassung:	This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration, and oxidation to give collections of quinoxalines in good to excellent yields. This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.06.115