Mechanism of incision by an apurinic-apyrimidinic endonuclease present in human placenta

An apparently homogeneous enzyme preparation, containing an apurinic/apyrimidinic (AP) endonuclease from human placenta, was by DNA sequencing analysis found to act as a class I AP-endonuclease, i.e. produce a 3'-deoxyribose and 5'-phosphomonoester nucleotide termini.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nucleic acids research 1989-07, Vol.17 (14), p.5529-5535
Hauptverfasser:	HAUKANES, B.-I, WITTWER, C.-U, HELLAND, D. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Bacteriophage phi X 174 - genetics Base Sequence Biological and medical sciences Deoxyribonuclease IV (Phage T4-Induced) DNA, Viral - genetics DNA-(Apurinic or Apyrimidinic Site) Lyase Endodeoxyribonucleases - isolation & purification Endodeoxyribonucleases - metabolism Enzymes and enzyme inhibitors Female Fundamental and applied biological sciences. Psychology Humans Hydrolases Molecular Sequence Data Placenta - enzymology Pregnancy Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	An apparently homogeneous enzyme preparation, containing an apurinic/apyrimidinic (AP) endonuclease from human placenta, was by DNA sequencing analysis found to act as a class I AP-endonuclease, i.e. produce a 3'-deoxyribose and 5'-phosphomonoester nucleotide termini.
ISSN:	0305-1048 1362-4962
DOI:	10.1093/nar/17.14.5529