Role of Mitochondrial Enzymes and Sarcoplasmic ATPase in Cardioprotection Mediated by Aqueous Extract of Desmodium gangeticum (L) DC Root on Ischemic Reperfusion Injury

Role of Mitochondrial Enzymes and Sarcoplasmic ATPase in Cardioprotection Mediated by Aqueous Extract of Desmodium gangeticum (L) DC Root on Ischemic Reperfusion Injury

The present study investigate the protective effect of aqueous root extract of Desmodium gangeticum in preserving mitochondrial and sarcoplasmic ATPase during ischemia reperfusion injury. The isolated rat hearts in both drug and control group were subjected to warm ischemia (37°), followed by reperf...

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Veröffentlicht in:Indian journal of pharmaceutical sciences 2010-11, Vol.72 (6), p.745-752
Hauptverfasser: Kurian, G A, Paddikkala, J
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine triphosphatase
Beans
Care and treatment
Diagnosis
Health aspects
Heart
Heart attacks
Heart rate
Kinases
Legumes
Materia medica, Vegetable
Mimosaceae
Physiological aspects
Plant extracts
Reperfusion injury
Research Paper
Rodents
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Zusammenfassung:The present study investigate the protective effect of aqueous root extract of Desmodium gangeticum in preserving mitochondrial and sarcoplasmic ATPase during ischemia reperfusion injury. The isolated rat hearts in both drug and control group were subjected to warm ischemia (37°), followed by reperfusion with the Langendorff perfusion system. The aqueous root extract of Desmodium gangeticum (L) at a dose of 50 mg/kg body weight was found to be effective in the rat heart for the management of ischemic reperfusion injury. Physiological parameters were significantly (P
ISSN:0250-474X
1998-3743
DOI:10.4103/0250-474X.84585