Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing

Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing

A novel cross-linked honey hydrogel dressing was developed by incorporating Malaysian honey into hydrogel dressing formulation, cross-linked and sterilized using electron beam irradiation (25 kGy). In this study, the physical properties of the prepared honey hydrogel and its wound healing efficacy o...

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Veröffentlicht in:Evidence-based complementary and alternative medicine 2012-01, Vol.2012 (2012), p.1-7
Hauptverfasser: Mohamed Mustapha, Noordin, Yusof, Norimah, Abu Bakar Zakaria, Md Zuki, Mohd Zohdi, Rozaini, Abdullah, Muhammad Nazrul Hakim
Format: Artikel
Sprache:eng
Schlagworte:
Apis mellifera
Biomedical materials
Crosslinking polymerization
Cytokines
Electron irradiation
Gene expression
Honey
Hydrogels
Inflammation
Inflammatory response
Interleukin 6
Irradiation
Medical dressings
Medical research
Melaleuca
Molecular chains
Molecular weight
Physical properties
Phytochemicals
Polyethylene glycol
Polymerase chain reaction
Radiation
Skin
Veterinary medicine
Wound healing
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Zusammenfassung:A novel cross-linked honey hydrogel dressing was developed by incorporating Malaysian honey into hydrogel dressing formulation, cross-linked and sterilized using electron beam irradiation (25 kGy). In this study, the physical properties of the prepared honey hydrogel and its wound healing efficacy on deep partial thickness burn wounds in rats were assessed. Skin samples were taken at 7, 14, 21, and 28 days after burn for histopathological and molecular evaluations. Application of honey hydrogel dressings significantly enhanced (P
ISSN:1741-427X
1741-4288
DOI:10.1155/2012/843025