Association of Relatively Low Serum Parathyroid Hormone With Malnutrition-Inflammation Complex and Survival in Maintenance Hemodialysis Patients

Background Low serum parathyroid hormone (PTH) has been implicated as a primary biochemical marker of adynamic bone disease in individuals with chronic kidney disease (CKD) who undergo maintenance hemodialysis (MHD) treatment. We hypothesized that the malnutrition-inflammation complex is associated...

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Veröffentlicht in:	Journal of renal nutrition 2010-07, Vol.20 (4), p.243-254
Hauptverfasser:	Dukkipati, Ramanath, MD, Kovesdy, Csaba P., MD, Colman, Sara, RD, Budoff, Matthew J., MD, Nissenson, Allen R., MD, Sprague, Stuart M., DO, Kopple, Joel D., MD, Kalantar-Zadeh, Kamyar, MD, MPH, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - blood Biomarkers - blood Bone Density - physiology Female Follow-Up Studies Humans Inflammation - blood Inflammation - mortality Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Kidney Failure, Chronic - mortality Male Middle Aged Nephrology Parathyroid Hormone - blood Protein-Energy Malnutrition - blood Protein-Energy Malnutrition - mortality Renal Dialysis Survival Analysis
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Zusammenfassung:	Background Low serum parathyroid hormone (PTH) has been implicated as a primary biochemical marker of adynamic bone disease in individuals with chronic kidney disease (CKD) who undergo maintenance hemodialysis (MHD) treatment. We hypothesized that the malnutrition-inflammation complex is associated with low PTH levels in these patients and confounds the PTH-survival association. Methods We examined 748 stable MHD outpatients in southern California and followed them for up to 5 years (October 2001–December 2006). Results In 748 MHD patients, serum PTH
ISSN:	1051-2276 1532-8503
DOI:	10.1053/j.jrn.2009.10.006