TGFBI expression reduces in vitro and in vivo metastatic potential of lung and breast tumor cells

Highlights ► TGFBI induces tumor cell adhesion and consequently led to cells less motile. ► TGFBI reduces tumor cell colony formation and penetration through matrix gel. ► TGFBI decreases activities of matrix metalloproteinases 2 and 9. ► TGFBI suppresses tumor cell metastasis in vivo.

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Veröffentlicht in:	Cancer letters 2011-09, Vol.308 (1), p.23-32
Hauptverfasser:	Wen, Gengyun, Partridge, Michael A, Li, Bingyan, Hong, Mei, Liao, Wupeng, Cheng, Simon K, Zhao, Yongliang, Calaf, Gloria M, Liu, Tian, Zhou, Jun, Zhang, Zengli, Hei, Tom K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion-mediated signaling agar Animals breast neoplasms Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology cell adhesion Cell Adhesion - physiology Cell Line, Tumor Cytoskeleton - metabolism Cytoskeleton - pathology Disease Models, Animal Extracellular matrix Female gels Hematology, Oncology and Palliative Medicine Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism metalloproteinases Metastasis Mice Mouse model Neoplasm Metastasis proteins Signal Transduction TGFBI Transfection Transforming Growth Factor beta1 - biosynthesis Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism
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Zusammenfassung:	Highlights ► TGFBI induces tumor cell adhesion and consequently led to cells less motile. ► TGFBI reduces tumor cell colony formation and penetration through matrix gel. ► TGFBI decreases activities of matrix metalloproteinases 2 and 9. ► TGFBI suppresses tumor cell metastasis in vivo.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2011.04.010