John Cunningham Virus Antibody and Viremia as Predictors of Progressive Multifocal Leukoencephalopathy in Human Immunodeficiency Virus-1-Infected Individuals

John Cunningham Virus Antibody and Viremia as Predictors of Progressive Multifocal Leukoencephalopathy in Human Immunodeficiency Virus-1-Infected Individuals

We examined whether prediagnostic John Cunningham virus (JCV) antibodies and viremia are predictors of progressive multifocal leukoencephalopathy (PML) in 83 PML cases and 240 human immunodeficiency virus (HIV) disease-matched controls. JCV viremia was not predictive of PML, but some patients showed...

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Veröffentlicht in:Clinical infectious diseases 2011-10, Vol.53 (7), p.711-711
Hauptverfasser: Viscidi, Raphael P, Khanna, Nina, Tan, Chen S, Li, Xiuhung, Jacobson, Lisa, Clifford, David B, Nath, Avindra, Margolick, Joseph B, Shah, Keerti V, Hirsch, Hans H, Koralnik, Igor J
Format: Artikel
Sprache:eng
Schlagworte:
HIV
HIV/AIDS
Human immunodeficiency virus
Immunoglobulins
Medical diagnosis
Viral infections
Viruses
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Zusammenfassung:We examined whether prediagnostic John Cunningham virus (JCV) antibodies and viremia are predictors of progressive multifocal leukoencephalopathy (PML) in 83 PML cases and 240 human immunodeficiency virus (HIV) disease-matched controls. JCV viremia was not predictive of PML, but some patients showed higher anti-JCV immunoglobulin G (IgG) responses 6 months prior to diagnosis. [PUBLICATION ABSTRACT]
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cir507