Phosphoryl- EZH-ion

Polycomb group (PcG) proteins regulate gene expression in embryonic and adult stem cells, but the mechanisms responsible for PcG gene targeting and regulation remain largely unknown. Recent evidence shows that EZH2, the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), is a nuclear phosphop...

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Veröffentlicht in:	Cell stem cell 2011-03, Vol.8 (3), p.262-265
Hauptverfasser:	Caretti, Giuseppina, Palacios, Daniela, Sartorelli, Vittorio, Puri, Pier Lorenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Cycle Cell differentiation, maturation, development, hematopoiesis Cell physiology Extracellular Signal-Regulated MAP Kinases - metabolism Fundamental and applied biological sciences. Psychology Humans Models, Biological Molecular and cellular biology Phosphorylation Signal Transduction Transcription Factors - metabolism
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Beschreibung
Zusammenfassung:	Polycomb group (PcG) proteins regulate gene expression in embryonic and adult stem cells, but the mechanisms responsible for PcG gene targeting and regulation remain largely unknown. Recent evidence shows that EZH2, the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), is a nuclear phosphoprotein linking cell-cycle-intrinsic or extracellular signals to specific epigenetic signatures.
ISSN:	1934-5909 1875-9777 1875-9777
DOI:	10.1016/j.stem.2011.02.012