The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk

Eleven single-nucleotide polymorphisms (SNPs) spanning OPRD1 were examined in 1063 European Americans (EAs) (620 cases with substance dependence (SD), including 557 with alcohol dependence (AD), 225 with cocaine dependence (CD) and 111 with opioid dependence (OD), and 443 controls). Nominally signif...

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Veröffentlicht in:	Molecular psychiatry 2008-05, Vol.13 (5), p.531-543
Hauptverfasser:	Zhang, H, Kranzler, H R, Yang, B-Z, Luo, X, Gelernter, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictive behaviors Adolescent Adult Adult and adolescent clinical studies Aged Alcohol Alcoholism Alcoholism - genetics Alleles Analgesics Behavioral Sciences Biological and medical sciences Biological Psychology Case-Control Studies Cocaine Cocaine-Related Disorders - genetics Dopamine Drug abuse Drug addiction Drug dependence Europe - ethnology Exons - genetics Female Gene frequency Genetic aspects Genetic Predisposition to Disease Haplotypes Haplotypes - genetics Health aspects Heroin Dependence - genetics Humans Linkage Disequilibrium Male Medical sciences Medicine Medicine & Public Health Middle Aged Morphine Narcotics Neurosciences Opioids original-article Peptides Pharmacotherapy Polymorphism, Single Nucleotide Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors Receptors, Opioid, delta - genetics Receptors, Opioid, delta - physiology Receptors, Opioid, kappa - genetics Receptors, Opioid, kappa - physiology Regression analysis Risk Risk factors Single nucleotide polymorphisms Single-nucleotide polymorphism Substance-Related Disorders - genetics United States - epidemiology
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Zusammenfassung:	Eleven single-nucleotide polymorphisms (SNPs) spanning OPRD1 were examined in 1063 European Americans (EAs) (620 cases with substance dependence (SD), including 557 with alcohol dependence (AD), 225 with cocaine dependence (CD) and 111 with opioid dependence (OD), and 443 controls). Nominally significant associations ( P
ISSN:	1359-4184 1476-5578
DOI:	10.1038/sj.mp.4002035