Total Synthesis of the Natural Product (±)-Dibromophakellin and Analogues

Total Synthesis of the Natural Product (±)-Dibromophakellin and Analogues

(±)-Dibromophakellin has been synthesized in two steps from a known alkene intermediate. The key step in the synthesis is the NBS olefin activation to facilitate the addition of a guanidine molecule across the double bond.

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Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2011-09, Vol.13 (17), p.4550-4553
Hauptverfasser: Hewlett, Nicole M, Tepe, Jetze J
Format: Artikel
Sprache:eng
Schlagworte:
Biological Factors - chemical synthesis
Biological Factors - chemistry
Heterocyclic Compounds, 4 or More Rings - chemical synthesis
Heterocyclic Compounds, 4 or More Rings - chemistry
Molecular Structure
Stereoisomerism
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Zusammenfassung:(±)-Dibromophakellin has been synthesized in two steps from a known alkene intermediate. The key step in the synthesis is the NBS olefin activation to facilitate the addition of a guanidine molecule across the double bond.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol201741r