A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection

A Simple Bias Correction in Linear Regression for Quantitative Trait Association Under Two-Tail Extreme Selection

Selective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias.

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Veröffentlicht in:Behavior genetics 2011-09, Vol.41 (5), p.776-779
Hauptverfasser: Kwan, Johnny S. H., Kung, Annie W. C., Sham, Pak C.
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Behavioral Science and Psychology
Bias
Clinical Psychology
Epistasis, Genetic
Extremes
Genetics
Genotype
Genotype & phenotype
Health Psychology
Humans
Linear regression analysis
Models, Genetic
Models, Statistical
Phenotype
Power
Psychology
Public Health
Quantitative Trait, Heritable
Regression Analysis
Reproducibility of Results
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Beschreibung
Zusammenfassung:Selective genotyping can increase power in quantitative trait association. One example of selective genotyping is two-tail extreme selection, but simple linear regression analysis gives a biased genetic effect estimate. Here, we present a simple correction for the bias.
ISSN:0001-8244
1573-3297
DOI:10.1007/s10519-011-9475-0