Survival and prognostic factors in hepatitis B virus-related acute-on-chronic liver failure

AIM：To investigate the survival rates and prognostic factors in patients with hepatitis B virus-related acuteon-chronic liver failure（HBV-ACLF）.METHODS：Clinical data in hospitalized patients with HBV-ACLF admitted from 2006 to 2009 were retrospectively analyzed.Their general conditions and survival were analyzed by survival analysis and Cox regression analysis.RESULTS：A total of 190 patients were included in this study.The overall 1-year survival rate was 57.6%.Patients not treated with antiviral drugs had a significantly higher mortality[relative risk（RR）=0.609,P=0.014].The highest risk of death in patients with ACLF was associated with hepatorenal syndrome（HRS）（RR=2.084,P=0.026）,while other significant factors were electrolyte disturbances（RR=2.062,P=0.010）,and hepatic encephalopathy（HE）（RR=1.879,P0.001）.CONCLUSION：Antiviral therapy has a strong effect on the prognosis of the patients with HBV-ACLF by improving their 1-year survival rate.HRS,electrolyte disturbances,and HE also affect patient survival.