Delta inulin polysaccharide adjuvant enhances the ability of split-virion H5N1 vaccine to protect against lethal challenge in ferrets

Abstract Background The reduced immunogenicity of the H5 hemagglutinin (HA), compared to seasonal HA serotypes, has stimulated searches for effective adjuvants to improve H5 vaccine efficacy. This study examined the immunogenicity and protective efficacy in ferrets immunized with a split-virion H5N1...

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Veröffentlicht in:Vaccine 2011-08, Vol.29 (37), p.6242-6251
Hauptverfasser: Layton, R. Colby, Petrovsky, Nikolai, Gigliotti, Andrew P, Pollock, Zemmie, Knight, Jennifer, Donart, Nathaniel, Pyles, John, Harrod, Kevin S, Gao, Peng, Koster, Frederick
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Sprache:eng
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