Organization and function of the FKBP52 and FKBP51 genes

Highlights ► FKBP4 and FKBP5 have similar genomic organization, but differ in size. ► FKBP52 and FKBP51 exhibit similar domain structure. ► Recent studies on the functions of FKBP52 and FKBP51 are summarized. ► FKBP52 and FKBP51 affect microtubule assembly through association with tau protein. ► FKB...

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Veröffentlicht in:	Current opinion in pharmacology 2011-08, Vol.11 (4), p.308-313
Hauptverfasser:	Cioffi, Donna L, Hubler, Tina R, Scammell, Jonathan G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Chordata epigenetics Gene Expression Regulation Humans immunophilins Internal Medicine Ion channels Medical Education Microtubule-associated proteins Microtubules - metabolism Molecular weight Neoplasms - pathology Nervous system Nervous System - metabolism Reproduction Reproduction - physiology Reviews Steroid hormone receptors Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - metabolism Transient Receptor Potential Channels - metabolism transient receptor potential proteins
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Beschreibung
Zusammenfassung:	Highlights ► FKBP4 and FKBP5 have similar genomic organization, but differ in size. ► FKBP52 and FKBP51 exhibit similar domain structure. ► Recent studies on the functions of FKBP52 and FKBP51 are summarized. ► FKBP52 and FKBP51 affect microtubule assembly through association with tau protein. ► FKBP52 (and possibly FKBP51) interacts with transient receptor potential channels.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2011.03.013