Studies on carcinogenic and toxic effects of ochratoxin A in chicks
Carcinogenic/toxic effects of ochratoxin A (OTA) in various internal organs of Plymouth Rock chicks were determined. The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE...
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| Veröffentlicht in: | Toxins 2010-04, Vol.2 (4), p.649-664 |
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| description | Carcinogenic/toxic effects of ochratoxin A (OTA) in various internal organs of Plymouth Rock chicks were determined. The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE cannot be used as a real protector against the carcinogenic or toxic effects of OTA in chicks. OTA was found to provoke strong degenerative changes in liver and kidneys, degenerative changes and depletion of cells in lymphoid organs, oedematous and degenerative changes in the brain, muscular haemorrhages and fatty changes in the bone marrow. The target organs for carcinogenic effect of OTA in chicks were found to be kidneys and liver. |
| doi_str_mv | 10.3390/toxins2040649 |
| format | Article |
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The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE cannot be used as a real protector against the carcinogenic or toxic effects of OTA in chicks. OTA was found to provoke strong degenerative changes in liver and kidneys, degenerative changes and depletion of cells in lymphoid organs, oedematous and degenerative changes in the brain, muscular haemorrhages and fatty changes in the bone marrow. The target organs for carcinogenic effect of OTA in chicks were found to be kidneys and liver.</description><identifier>ISSN: 2072-6651</identifier><identifier>EISSN: 2072-6651</identifier><identifier>DOI: 10.3390/toxins2040649</identifier><identifier>PMID: 22069604</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Bone marrow ; Chickens ; Female ; Kidney - drug effects ; Kidney - pathology ; Kidney Neoplasms - chemically induced ; Kidney Neoplasms - pathology ; Kidneys ; Liver - drug effects ; Liver - pathology ; Liver Neoplasms, Experimental - chemically induced ; Liver Neoplasms, Experimental - pathology ; Male ; Mycotoxins - toxicity ; Neoplasms, Experimental - chemically induced ; Ochratoxin A ; Ochratoxins - toxicity</subject><ispartof>Toxins, 2010-04, Vol.2 (4), p.649-664</ispartof><rights>Copyright MDPI AG 2010</rights><rights>2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-1caeb8a50500d45fe1f80d4b1b40af1c458ff1fafe84a0c016cf930015b667943</citedby><cites>FETCH-LOGICAL-c414t-1caeb8a50500d45fe1f80d4b1b40af1c458ff1fafe84a0c016cf930015b667943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153202/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153202/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22069604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stoev, Stoycho D</creatorcontrib><title>Studies on carcinogenic and toxic effects of ochratoxin A in chicks</title><title>Toxins</title><addtitle>Toxins (Basel)</addtitle><description>Carcinogenic/toxic effects of ochratoxin A (OTA) in various internal organs of Plymouth Rock chicks were determined. The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE cannot be used as a real protector against the carcinogenic or toxic effects of OTA in chicks. OTA was found to provoke strong degenerative changes in liver and kidneys, degenerative changes and depletion of cells in lymphoid organs, oedematous and degenerative changes in the brain, muscular haemorrhages and fatty changes in the bone marrow. The target organs for carcinogenic effect of OTA in chicks were found to be kidneys and liver.</description><subject>Animals</subject><subject>Bone marrow</subject><subject>Chickens</subject><subject>Female</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Kidney Neoplasms - chemically induced</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidneys</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Liver Neoplasms, Experimental - chemically induced</subject><subject>Liver Neoplasms, Experimental - pathology</subject><subject>Male</subject><subject>Mycotoxins - toxicity</subject><subject>Neoplasms, Experimental - chemically induced</subject><subject>Ochratoxin A</subject><subject>Ochratoxins - toxicity</subject><issn>2072-6651</issn><issn>2072-6651</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpVkM1LAzEQxYMottQevcqC59XJx2Z3L0IpfkHBg3oO2WzSprZJTbai_72praWdw8zA_HhveAhdYrihtIbbzn9bFwkw4Kw-QX0CJck5L_Dpwd5DwxjnkIpSXOPyHPUIAV5zYH00fu3WrdUx8y5TMijr_FQ7qzLp2mwjrzJtjFZdIkzm1SzIP9NslKWmZlZ9xAt0ZuQi6uFuDtD7w_3b-CmfvDw-j0eTXDHMuhwrqZtKFlAAtKwwGpsqLQ1uGEiDFSsqY7CRRldMggLMlakpAC4azsua0QG62-qu1s1St0q7LsiFWAW7lOFHeGnF8cXZmZj6L0FxQQmQJHC9Ewj-c61jJ-Z-HVz6WSSirEuCycYm31Iq-BiDNnsHDGITuziKPfFXh2_t6f-Q6S8h139F</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Stoev, Stoycho D</creator><general>MDPI AG</general><general>Molecular Diversity Preservation International</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>5PM</scope></search><sort><creationdate>20100401</creationdate><title>Studies on carcinogenic and toxic effects of ochratoxin A in chicks</title><author>Stoev, Stoycho D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-1caeb8a50500d45fe1f80d4b1b40af1c458ff1fafe84a0c016cf930015b667943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Bone marrow</topic><topic>Chickens</topic><topic>Female</topic><topic>Kidney - 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The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE cannot be used as a real protector against the carcinogenic or toxic effects of OTA in chicks. OTA was found to provoke strong degenerative changes in liver and kidneys, degenerative changes and depletion of cells in lymphoid organs, oedematous and degenerative changes in the brain, muscular haemorrhages and fatty changes in the bone marrow. The target organs for carcinogenic effect of OTA in chicks were found to be kidneys and liver.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>22069604</pmid><doi>10.3390/toxins2040649</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Bone marrow Chickens Female Kidney - drug effects Kidney - pathology Kidney Neoplasms - chemically induced Kidney Neoplasms - pathology Kidneys Liver - drug effects Liver - pathology Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - pathology Male Mycotoxins - toxicity Neoplasms, Experimental - chemically induced Ochratoxin A Ochratoxins - toxicity |
| title | Studies on carcinogenic and toxic effects of ochratoxin A in chicks |
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